Novel Uses for Lipid-Lowering Agents

Novel Uses for Lipid-Lowering Agents

Statin use leads to a reduction in the downstream products of the mevalonate pathway. Knowledge of this pathway has led scientists to investigate the role of statins in cancer prevention and treatment. Statins appear to possess a variety of pleiotropic effects, including inhibition of cell proliferation; enhanced apoptosis; and modulation of inflammation, endothelial function, and angiogenesis....

Guideline on Lipid Lowering agents

Novel 5-substituted-1H-tetrazole derivatives as potent glucose and lipid lowering agents.

A series of 5-(4-alkoxyphenylalkyl)-1H-tetrazole derivatives, containing an oxazole-based group at the alkoxy moiety, was prepared and their antidiabetic effects were evaluated in two genetically obese and diabetic animal models, KKAy mice and Wistar fatty rats. Syntheses were performed by cyclization of the corresponding nitrites reacting with azide compounds. A large number of the 5-(4-alkoxy...

Successful Treatment of Xanthoma Disseminatum with Combined Lipid Lowering Agents

Received October 18, 2011, Revised November 29, 2011, Accepted for publication November 30, 2011 Corresponding author: Moon-Bum Kim, M.D., Ph.D., Department of Dermatology, Pusan National University Hospital, Pusan National University School of Medicine, 179 Gudeok-ro, Seo-gu, Busan, 602-739, Korea. Tel: 82-51-240-7338, Fax: 82-51-245-9467, E-mail: [email protected] This is an Open Access artic...

Use of lipid-lowering agents (statins) during pregnancy.

QUESTION A 34-year-old patient of mine is taking a 'statin' for hyperlipidemia. She is planning pregnancy and is worried about the safety of the drug. How should I advise her? ANSWER Limited evidence from animal and human studies indicates that statins should not be taken during pregnancy. If a patient is inadvertently exposed during pregnancy, however, termination does not appear to be medic...